Oligomerization and conformational changes within the MSP
Oligomerization and conformational changes within the MSP are required for VAP-B(P56S) aggregation and neurotoxicity
Oligomerization and conformational changes within the MSP are required for VAP-B(P56S) aggregation and neurotoxicity
We defined the structural requirements for VAP-B oligomerization and demonstrated their contribution for VAP-B(P56S) aggregation and neurotoxicity. We show that the oligomerization of VAP-B is mainly mediated by its coiled-coil domain, and that the GXXXG dimerization motif within the transmembrane… Continue Reading
Potential mechanisms underlying the aggregation and motor neurodegeneration of VAP-B (P56S) mutant.