Potential mechanisms underlying the aggregation and motor neurodegeneration of VAP-B(P56S) mutant. The Lev’s lab found that the P56S mutation enhances the exposure of hydrophobic patches which together with the coiled-coil domain facilitate VAP-B(P56S) oligomerization and aggregation thereby preventing the binding… Continue Reading
Oligomerization and conformational changes within the MSP are required for VAP-B(P56S) aggregation and neurotoxicity
Multilamellar ER-derived membrane structures called ‘Karmellea’ were associated with VAP-B(P56S) as reported by Gkogkas et al., J. Neurochem. 2011
Prof. Sima Lev’ team showed that the three Nir proteins interact with VAP-B, but each interaction affects the structural integrity of the ER membranes differently. Whereas the Nir2-VAP-B interaction induces the formation of stacked ER membrane arrays as demonstrated by… Continue Reading
Prof. Sima Lev’ team showed that the Nir2 protein mainly localizes to the Golgi in interphase cells, and isolated the integral ER-membrane protein VAP-B as Nir2-interacting protein. They showed that Nir2-VAP-B interaction is mediated by the FFAT (EFFDAxE) motif within… Continue Reading
The Nir/rdgB family of proteins has been identified in a variety of eukaryotic organisms, ranging from worms to mammals. The Drosophila retinal degeneration B (rdgB), a protein that is required for photoreceptor cell viability and light response, was the first… Continue Reading
The Nir Proteins Family, Nir2 functions at ER-Golgi MCSs, Co-expression of Nirs with VAPs distinctly affects the ER morphology.