The human SNAREs

The SNARE hypothesis was first introduced in 1993 and suggested that a v-SNARE on the vesicle pairs with cognate t-SNAREs on the target membrane to form a complex that not only determines the specificity of the fusion but also catalyzes the actual fusion process.  Since then many SNAREs have been identified of which, 38 SNAREs are known to exist in Humans. The helix-forming units are so-called SNARE motifs, stretches of 60–70 amino acids containing heptad repeats with a central 0 layer. Based on the sequence and the amino acid located in the central 0 layer, SNAREs are classified into four subclasses: Qa-, Qb-, Qc-, and R-SNAREs. The Q-SNAREs usually function as t-SNAREs and the R-SNAREs as v-SNAREs. Shown is domain organization of human SNAREs. The indicated SNAREs along with their corresponding domains are shown. TM: transmembrane domain.

Slide 3: The human SNAREs
Sima Lev: The human SNAREs

Sima Lev Web Team

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