Senior author Sima Lev says this probably allows the two transport steps to be coordinated. She now wants to investigate whether COG subunits interact with additional components of the TGN fusion machinery.
Prof. Sima Lev and her student Orly Laufman revealed how a membrane-tethering complex promotes the transport of vesicles from endosomes to the trans-Golgi network (TGN). The conserved oligomeric Golgi (COG) complex helps to recycle proteins back through the Golgi apparatus… Continue Reading
Prof. Sima Lev and her team identified a unique direct interaction between Cog4 and the SM protein Sly. Link Laufman et al., EMBO J. 2009.
The octameric COG complex (Cog1–8), regulates intra-Golgi and endosome-to-Golgi retrograde transport, interact with the SNARE motifs of multiple Golgi SNAREs. Prof. Sima Lev extensively studied the function of COG in mammalian cells.
Multisubunit tethering complexes (MTCs) interact with soluble SNAREs to couple vesicular tethering with fusion. Conserved Oligomeric Golgi (COG) and Golgi-associated retrograde protein (GARP) MTCs interact with multiple SNAREs on the Golgi membranes. The eight subunits of the COG complex are… Continue Reading
Tethering factors are a large group of proteins or multiple-protein complexes that link transport vesicles to their cognate target membranes. Tethering factors can be divided into two major groups: homodimeric long coiled-coil proteins and multisubunit tethering complexes (MTCs). Coiled-coil tethers… Continue Reading