Structural requirements for VAP-B oligomerization and their implication in Als-associated VAP-B (P56S) neurotoxicity

slid #6 From Sima Lev's presentation - VAP-B and its role in Amyotrophic lateral sclerosis

We defined the structural requirements for VAP-B oligomerization and demonstrated their contribution for VAP-B(P56S) aggregation and neurotoxicity. We show that the oligomerization of VAP-B is mainly mediated by its coiled-coil domain, and that the GXXXG dimerization motif within the transmembrane… Continue Reading

Prof. Sima Lev: VAP-B and its role in Amyotrophic lateral sclerosis

Prof. Sima Lev - VAP-B and its role in Amyotrophic lateral sclerosis

The VAPs (VAMP-associated proteins) are highly conserved integral endoplasmic reticulum (ER)-membrane proteins, implicated in diverse cellular functions, including regulation of lipid transport and homeostasis, membrane trafficking, neurotransmitter release, stabilization of presynaptic microtubules, and the unfolded protein response (UPR). A single… Continue Reading