The N-terminal Cytoplasmic MSP (Major Sperm Protein) Domain

The N-terminal cytoplasmic MSP (major sperm protein) domain of VAP-B consistes of 125 amino acids (aa), and a coiled-coil domain (CCD) of ~50 aa. Proline 56 resides within a highly conserved sequence of 16 aa in the MSP
domain in a cis-peptide bond conformation, therefore, the serine substitution induces its cis-to-trans isomerization. By using set of truncated mutants of VAP-B, we found that the oligomerization of the wild-type VAP-B is independent of its MSP domain.

slide #7 From Sima Lev's presentation - VAP-B and its role in Amyotrophic lateral sclerosis
From prof. Sima Lev’s presentation –VAP-B and its role in Amyotrophic lateral sclerosis

Sima Lev Web Team

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