Nir2, CERT and OSBP coordinately function at the ER-Golgi MCSs

Sima Lev: Nir2, CERT and OSBP coordinately function

Nir2, CERT and OSBP are three lipid-transfer proteins containing an FFAT motif, interact with VAP-A/B and localize to the Golgi apparatus at steady-state. Targeting of OSBP and CERT to the Golgi is mediated by their PH domains which bind PI4P on the Golgi membranes. Knockdown of VAP-A/B reduced the Golgi localization of OSBP, CERT and Nir2 and concomitantly the Golgi levels of DAG, PI4P and SM, and Golgi mediated transport to the plasma membrane and endosomes.

Sima Lev Web Team

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