COG interacts with multiple Golgi SNAREs via its multi subunits
Prof. Sima Lev
Cog6 knockdown affects the steady-state distribution of Stx6-associated SNARE complex
Prof. Sima Lev and her student Orly Laufman revealed how a membrane-tethering complex promotes the transport of vesicles from endosomes to the trans-Golgi network (TGN). The conserved oligomeric Golgi (COG) complex helps to recycle proteins back through the Golgi apparatus… Continue Reading
Oligomerization and conformational changes within the MSP
Oligomerization and conformational changes within the MSP are required for VAP-B(P56S) aggregation and neurotoxicity
The Nir Proteins Family
The Nir/rdgB family of proteins has been identified in a variety of eukaryotic organisms, ranging from worms to mammals. The Drosophila retinal degeneration B (rdgB), a protein that is required for photoreceptor cell viability and light response, was the first… Continue Reading
p56S Insoluble Aggregates
Characterization of p56S insoluble aggregates. Analysis of the solubilization of the indicated mutants suggest that the oligomerization of VAP-B(P56S) is mediated mainly by the coiled-coil domain and that the GXXXG also contributes to VAP-B(P56S) oligomerization and consequently for the production… Continue Reading
The N-terminal Cytoplasmic MSP (Major Sperm Protein) Domain
The N-terminal cytoplasmic MSP (major sperm protein) domain of VAP-B consistes of 125 amino acids (aa), and a coiled-coil domain (CCD) of ~50 aa. Proline 56 resides within a highly conserved sequence of 16 aa in the MSP domain in… Continue Reading
Prof. Sima Lev – Regulatio of Golgi structure and function in interphase and mitotic cells
The Golgi apparatus (discovered by Camillo Golgi), is the central organelle of the secretory pathway, involved in the post-translational modification of many cellular proteins and lipids and their sorting to appropriate subcellular destinations. Maintenance of the structural integrity of the Golgi… Continue Reading
Regulation of membrane trafficking by non-vesicular transport mechanisms
Membrane trafficking pathways are mediated by a network of proteins and lipids that coordinately function to efficiently and rapidly transport lipids, secreted, luminal and integral membrane proteins to their final cellular destinations. The tight regulation of membrane transport events is… Continue Reading
