Oligomerization and conformational changes within the MSP
Oligomerization and conformational changes within the MSP are required for VAP-B(P56S) aggregation and neurotoxicity
MSP
The N-terminal Cytoplasmic MSP (Major Sperm Protein) Domain
The N-terminal cytoplasmic MSP (major sperm protein) domain of VAP-B consistes of 125 amino acids (aa), and a coiled-coil domain (CCD) of ~50 aa. Proline 56 resides within a highly conserved sequence of 16 aa in the MSP domain in… Continue Reading
