Prof. Sima Lev
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MSP domain

The Effect of the P56S on FFAT Binding

April 9, 2019Sima Lev Web Team Leave a Comment
Slide #10 From Sima Lev's presentation - VAP-B and its role in Amyotrophic lateral sclerosis

Oligomerization of VAP-B(P56S) prevents binding of FFAT proteins. We found that the conformational changes of MSP domain of P56S mutant have no direct effect on FFAT-binding. Rather, they enhance VAP-B(P56S) oligomerization driven by the combined contributions of the coiled-coil and… Continue Reading →

VAP-B in ALS ALS, FFAT Binding, MSP domain, P56S, VAP-B

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Sima Lev and Nandini Verma in the lab
Sima Lev and Nandini Verma in the lab

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  • sima lev - Lipid Transfer Proteins and memrane in Human Cancer

    Lipid Transfer Proteins and Membrane Contact Sites in Human Cancer

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  • clinical trials

    The Annual Conference on Clinical Studies in Israel

    January 15, 2020
  • Prof. Sima Lev Will Give a Talk in the 4th Zavalkoff Symposium

    December 23, 2019
  • Sima Lev congratulate Weizmann Institute’s new President

    December 19, 2019
Sima Lev VAP-B ALS Prof. Sima Lev P56S VAP-B (P56S) VAP-B(P56S) Cog4 Weizmann Institute of Science SNARE endocytic pathways SNAREpin Assembly SNAREpin COG MSP neurotoxicity PI VAP ER-Golgi MCSs GXXXG Neurotoxic Effect Nir proteins in PI presentations The Nir Proteins Nir2 functions ER morphology ER membranes ER-derived membrane structure changes within the MSP FFAT protein Formation of insoluble protein MSP domain Nir FFAT Binding Amyotrophic lateral sclerosis WT and P56S mutant N-terminal Cytoplasmic TMD fALS Motor Neuron Diseases (MND) motor neurone disease P56S mutation mitotic cells Golgi structure unfolded protein response proteins lipids vesicular transport Membrane trafficking fluorophore Nir proteins Nir2 OSBP Stx5 Stx6 lecture cell imaging technology BIOCHEMICAL SOCIETY turin italy meeting lectures news non-fusogenic interactions Cell signaling seminar Congratulation Prof. Alon Chen new President Symposium Disease and Health Metabolism research disease Lipid Transfer Proteins human cancer special guest CERT professor sima lev Orly Laufman Membrane Fusion ER–Golgi MVB TGN PM Snare regulation Tethering Factors SM proteins Tethering complexes MTC membrane-tethering complex GARP SM Protein Sly1 Syntaxin 5 distinct adjacent binding sites Sly1 Cog4-KD GS15-Syntaxin 5 sima levs team TGN trafficking Cog6 knockdown Stx6-associated SNARE complex COG complex membrane contact sites

Regulatio of Golgi structure

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