Prof. Sima Lev
Membrane Trafficking | Health & Disease
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ER morphology

Co-expression of Nirs with VAPs distinctly affects the ER morphology

April 17, 2019Sima Lev Web Team Leave a Comment

Prof. Sima Lev’ team showed that the three Nir proteins interact with VAP-B, but each interaction affects the structural integrity of the ER membranes differently. Whereas the Nir2-VAP-B interaction induces the formation of stacked ER membrane arrays as demonstrated by… Continue Reading →

Nir proteins in PI ER membranes, ER morphology, Nir, VAP, VAP-B

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Sima Lev and Nandini Verma in the lab
Sima Lev and Nandini Verma in the lab

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Sima Lev disease research VAP-B ALS Prof. Sima Lev P56S VAP-B (P56S) VAP-B(P56S) Cog4 Weizmann Institute of Science COG endocytic pathways SNAREpin Assembly SNAREpin SNARE MSP neurotoxicity PI ER-Golgi MCSs VAP MSP domain GXXXG Neurotoxic Effect Nir proteins in PI presentations The Nir Proteins Nir2 functions ER morphology ER membranes ER-derived membrane structure changes within the MSP FFAT Binding Nir fluorophore mitotic cells N-terminal Cytoplasmic TMD fALS Motor Neuron Diseases (MND) motor neurone disease Amyotrophic lateral sclerosis Nir proteins FFAT protein unfolded protein response proteins lipids vesicular transport Membrane trafficking WT and P56S mutant Golgi structure Formation of insoluble protein Nir2 professor sima lev non-fusogenic interactions Stx5 Stx6 lecture cell imaging technology BIOCHEMICAL SOCIETY turin italy meeting membrane-tethering complex lectures Cell signaling seminar special guest Congratulation Prof. Alon Chen new President Symposium Disease and Health Metabolism Lipid Transfer Proteins human cancer news P56S mutation Orly Laufman Cog6 knockdown CERT OSBP Membrane Fusion ER–Golgi MVB TGN PM Snare regulation Tethering Factors SM proteins Stx6-associated SNARE complex Tethering complexes GARP COG complex SM Protein Sly1 Syntaxin 5 distinct adjacent binding sites Sly1 Cog4-KD GS15-Syntaxin 5 sima levs team TGN trafficking MTC membrane contact sites

Regulatio of Golgi structure

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