Prof. Sima Lev
Membrane Trafficking | Health & Disease
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ER-Golgi MCSs

Nir2, CERT and OSBP coordinately function at the ER-Golgi MCSs

April 23, 2019Sima Lev Web Team Leave a Comment

Nir2, CERT and OSBP are three lipid-transfer proteins containing an FFAT motif, interact with VAP-A/B and localize to the Golgi apparatus at steady-state. Targeting of OSBP and CERT to the Golgi is mediated by their PH domains which bind PI4P… Continue Reading →

Uncategorized CERT, ER-Golgi MCSs, Nir2, OSBP, VAP-B

Nir2 functions at ER-Golgi MCSs

April 16, 2019Sima Lev Web Team Leave a Comment

Prof. Sima Lev’ team showed that the Nir2 protein mainly localizes to the Golgi in interphase cells, and isolated the integral ER-membrane protein VAP-B as Nir2-interacting protein. They showed that Nir2-VAP-B interaction is mediated by the FFAT (EFFDAxE) motif within… Continue Reading →

Nir proteins in PI ER-Golgi MCSs, Nir2 functions, PI, VAP-B

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Sima Lev and Nandini Verma
Sima Lev and Nandini Verma in the lab
Sima Lev and Nandini Verma in the lab

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    Prof. Sima Lev – Regulatio of Golgi structure and function in interphase and mitotic cells

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  • Sima Lev reccomends: Regulation of the epithelial control gene p63 by oncogenes and the Hippo signaling pathway

    September 17, 2023
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    August 22, 2023
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Sima Lev disease research VAP-B ALS Prof. Sima Lev P56S VAP-B (P56S) VAP-B(P56S) Cog4 Weizmann Institute of Science COG endocytic pathways SNAREpin Assembly SNAREpin SNARE MSP neurotoxicity PI ER-Golgi MCSs VAP MSP domain GXXXG Neurotoxic Effect Nir proteins in PI presentations The Nir Proteins Nir2 functions ER morphology ER membranes ER-derived membrane structure changes within the MSP FFAT Binding Nir fluorophore mitotic cells N-terminal Cytoplasmic TMD fALS Motor Neuron Diseases (MND) motor neurone disease Amyotrophic lateral sclerosis Nir proteins FFAT protein unfolded protein response proteins lipids vesicular transport Membrane trafficking WT and P56S mutant Golgi structure Formation of insoluble protein Nir2 professor sima lev non-fusogenic interactions Stx5 Stx6 lecture cell imaging technology BIOCHEMICAL SOCIETY turin italy meeting membrane-tethering complex lectures Cell signaling seminar special guest Congratulation Prof. Alon Chen new President Symposium Disease and Health Metabolism Lipid Transfer Proteins human cancer news P56S mutation Orly Laufman Cog6 knockdown CERT OSBP Membrane Fusion ER–Golgi MVB TGN PM Snare regulation Tethering Factors SM proteins Stx6-associated SNARE complex Tethering complexes GARP COG complex SM Protein Sly1 Syntaxin 5 distinct adjacent binding sites Sly1 Cog4-KD GS15-Syntaxin 5 sima levs team TGN trafficking MTC membrane contact sites

Regulatio of Golgi structure

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