ER-Golgi MCSs Archives - Prof. Sima Lev

Nir2, CERT and OSBP coordinately function at the ER-Golgi MCSs

April 23, 2019Sima Lev Web Team Leave a Comment

Nir2, CERT and OSBP are three lipid-transfer proteins containing an FFAT motif, interact with VAP-A/B and localize to the Golgi apparatus at steady-state. Targeting of OSBP and CERT to the Golgi is mediated by their PH domains which bind PI4P… Continue Reading →

Nir2 functions at ER-Golgi MCSs

April 16, 2019Sima Lev Web Team Leave a Comment

Prof. Sima Lev’ team showed that the Nir2 protein mainly localizes to the Golgi in interphase cells, and isolated the integral ER-membrane protein VAP-B as Nir2-interacting protein. They showed that Nir2-VAP-B interaction is mediated by the FFAT (EFFDAxE) motif within… Continue Reading →

ER-Golgi MCSs

Nir2, CERT and OSBP coordinately function at the ER-Golgi MCSs

Nir2 functions at ER-Golgi MCSs

Regulation of membrane trafficking by non-vesicular transport mechanisms

Sima Lev: VAP-B and its role in Amyotrophic lateral sclerosis

Prof. Sima Lev – The role of Nir proteins in phosphatidylinositol (PI) transport and beyond

Prof. Sima Lev – Regulatio of Golgi structure and function in interphase and mitotic cells

Sima Lev reccomends: Regulation of the epithelial control gene p63 by oncogenes and the Hippo signaling pathway

Sima Lev recommends PYK2, a hub of signaling networks in breast cancer progression

Sima Lev recommends to watch: What You Need To Know About Triple Negative Breast Cancer

Sima Lev recommends to watch: Issues in Triple Negative Breast Cancer

Regulatio of Golgi structure