ER-Golgi MCSs Archives - Prof. Sima Lev

Nir2, CERT and OSBP coordinately function at the ER-Golgi MCSs

April 23, 2019Sima Lev Web Team Leave a Comment

Nir2, CERT and OSBP are three lipid-transfer proteins containing an FFAT motif, interact with VAP-A/B and localize to the Golgi apparatus at steady-state. Targeting of OSBP and CERT to the Golgi is mediated by their PH domains which bind PI4P… Continue Reading →

Nir2 functions at ER-Golgi MCSs

April 16, 2019Sima Lev Web Team Leave a Comment

Prof. Sima Lev’ team showed that the Nir2 protein mainly localizes to the Golgi in interphase cells, and isolated the integral ER-membrane protein VAP-B as Nir2-interacting protein. They showed that Nir2-VAP-B interaction is mediated by the FFAT (EFFDAxE) motif within… Continue Reading →

ER-Golgi MCSs

Nir2, CERT and OSBP coordinately function at the ER-Golgi MCSs

Nir2 functions at ER-Golgi MCSs

Regulation of membrane trafficking by non-vesicular transport mechanisms

Sima Lev: VAP-B and its role in Amyotrophic lateral sclerosis

Prof. Sima Lev – The role of Nir proteins in phosphatidylinositol (PI) transport and beyond

Prof. Sima Lev – Regulatio of Golgi structure and function in interphase and mitotic cells

Sima Lev recommends to read: Treatment advances in metastatic triple-negative breast cancer (TNBC)

Sima Lev recommends to read: Researchers identify regulator of breast cancer development

Sima Lev recommends IVS Webinar Prof. Ray Boxman

Single-cell approaches for studying spatial heterogeneity in the healthy and malignant liver

Regulatio of Golgi structure