Senior author Sima Lev says this probably allows the two transport steps to be coordinated. She now wants to investigate whether COG subunits interact with additional components of the TGN fusion machinery.
Multisubunit tethering complexes (MTCs) interact with soluble SNAREs to couple vesicular tethering with fusion. Conserved Oligomeric Golgi (COG) and Golgi-associated retrograde protein (GARP) MTCs interact with multiple SNAREs on the Golgi membranes. The eight subunits of the COG complex are… Continue Reading