Prof. Sima Lev – Regulatio of Golgi structure and function in interphase and mitotic cells

Sima Lev - Regulatio

The Golgi apparatus (discovered by Camillo Golgi), is the central organelle of the secretory pathway, involved in the post-translational modification of many cellular proteins and lipids and their sorting to appropriate subcellular destinations.  Maintenance of the structural integrity of the Golgi… Continue Reading

Sima Lev: VAP-B and its role in Amyotrophic lateral sclerosis

Prof. Sima Lev - VAP-B and its role in Amyotrophic lateral sclerosis

The VAPs (VAMP-associated proteins) are highly conserved integral endoplasmic reticulum (ER)-membrane proteins, implicated in diverse cellular functions, including regulation of lipid transport and homeostasis, membrane trafficking, neurotransmitter release, stabilization of presynaptic microtubules, and the unfolded protein response (UPR). A single… Continue Reading

Regulation of membrane trafficking by non-vesicular transport mechanisms

Membrane trafficking pathways are mediated by a network of proteins and lipids that coordinately function to efficiently and rapidly transport lipids, secreted, luminal and integral membrane proteins to their final cellular destinations. The tight regulation of membrane transport events is… Continue Reading