Single-cell approaches for studying spatial heterogeneity in the healthy and malignant liver
Prof. Shalev Itzkovitz
Department of Molecular Cell Biology
Faculty of Biology 11 November 2021.
The liver is a major site of primary tumors and metastases. It is a highly
heterogeneous organ that is composed of repeating anatomical units with graded
microenvironments. Understanding liver function in health and disease, therefore,
requires resolving cell identities in their spatial context. In my talk, I will describe
spatially-resolved single-cell and paired-cell approaches that enable reconstructing
the identities and functions of diverse liver cell types. I will then demonstrate
insights gained from such analyses on the human liver tumor microenvironment.
